During is a preposition and it's always followed by a noun.
While is a linking word and it's always followed by a clause.
During es una preposición y siempre va seguida de un sustantivo.
While es un conector y siempre va seguido de una oración subordinada.
She usually watches TV during lunch.
You should take notes during the conference.
We went to the theatre during our stay in Paris.
She usually watches TV while she's having lunch.
Joe invited his friends home while his parents were on holiday.
Your sister called you while you were at work.
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